Mike Monument, MD, FRCSC

Research description:

As an orthopaedic surgeon and researcher, specializing in the diagnosis and management of malignant pediatric bone cancers, such as osteosarcoma and Ewing sarcoma, Dr. Monument's research program is interested in how these bone cancers metastasize to the lung. Lung metastases substantially increase the risk of mortality in children and young adults diagnosed with malignant bone cancers, and yet very little in known about why bone sarcomas have such strong avidity for the lung. Utilizing pre-clinical models, high-end genetic sequencing and imaging technology, his lab is studying different human bone sarcoma models to characterize common genetic and molecular factors responsible for lung metastases. Identification of these crucial pro-metastatic pathways is needed to facilitate early recognition of high-risk patients and discover new, targeted therapies.


Other research interests include genetic susceptibility to Ewing sarcoma, bio-banking of pre-treatment bone and soft tissue sarcoma tissue, and benign fibroproliferative disorders such post-traumatic joint contractures and desmoid tumors.


PubMed link: